Scientific Program (Oral Abstracts) | Poster Abstracts | Speaker List
SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
SCIENTIFIC PROGRAM
(Oral Abstracts)Soy and Bone Health
A Soy Protein-Containing Diet Prevents Bone Loss Due to Ovarian Hormone Deficiency
B.H. Arjmandi, M.J. Getlinger, N.V. Goyal, 1R. Birnbaum. Department of Human Nutrition and Dietetics, University of Illinois at Chicago 60612; 1VA Medical Center, Tacoma, WA 98493.Ipriflavone, a synthetic isoflavone, has been reported to have a beneficial effect on bone. The success of this compound for treatment of bone loss in models of osteoporosis and in clinical trials led us to examine the ability of soy protein, a rich source of naturally occurring isoflavones, to prevent or reverse bone loss due to ovarian hormone deficiency. In a prevention study, treatment was initiated following surgery. Forty-eight 95-d old rats were divided into groups: sham, ovariectomized (ovx), ovx fed soy protein isolate with isoflavones (soy +), and ovx fed soy protein isolate without isoflavones (soy-). Thirty-five days after surgery, the animals were sacrificed. The (soy+) diet prevented the decrease in femoral bone density (g/cm3 bone) seen in the ovx and (soy-) groups (mean+/-SD; 1.522 +/-0.041, 1.449+/-0.044, 1.497+/-0.030, 1.452+/-0.030, respectively for sham, ovx, soy+, and soy- groups). Increase in serum IGF-I, IGFBP-3, alkaline phosphatase, and tartrate-resistant acid phosphatase following ovx were unchanged in the (soy+) animals. In an intervention study, treatment was initiated 35 d following surgery. 60 95-d old rats were divided into 5 groups: 2 sham and 3 ovx. One sham and one ovx group were sacrificed on day 35; soy protein diets (soy+) and (soy-) were then initiated for the 2 remaining ovx groups. Ovx resulted in decreased femoral bone density, but the (soy+) diet did not reverse this bone loss. Our observations suggest that soy protein containing isoflavones is effective in preventing, but cannot reverse, bone loss at least during a relatively short treatment period. We suggest that a diet supplemented with soy protein isolate may be an effective method to prevent post menopausal bone loss.
Supported in part by a grant from the Illinois Soybean Program Operating Board.
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