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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASE

SCIENTIFIC PROGRAM
(Oral Abstracts)

Index

• Opening Day Abstracts
• Soy and Kidney Function
• Soy and Bone Health
• Soy and Heart Disease
  • Hypocholesterolemic Effects of Soy
  • Hypocholesterolemic Effects of Soy: Potential Mechanisms
  • Effects Independent of Cholesterol Reduction
• Soy and Cancer
  • Animal Studies
  • Soybean Anticarcinogens/Anticancer Mechanisms
  • Soy Consumption and Cancer Risk: Human Studies
• Hormonal Effects of Soy
  • Premenopausal Studies
  • Postmenopausal Studies
• Current Understanding of Soy and Infant Health
• Soybean Isoflavones : Levels in Foods and Pharmacokinetics

September 15

Opening Day Abstracts

• Cancer Prevention: Food and Phytochemicals
  John Potter
  
  Biotechnology and the soybean
  Stephen Rogers
  
  Keynote Address : Overview of isoflavone structure, metabolism and pharmacokinetics
  Kenneth D.R. Setchell
  
  Use of soy proteins in cholelithiasis prevention
  Isabelle Catala
  
  Effects of isoflavones on alcohol pharmacokinetics and alcohol drinking behavior
  Renee Lin

September 16

Soy and Kidney Function
(Chair, James W. Anderson)

• Soy consumption and renal function in patients with nephrotic syndrome: clinical effects and potential mechanisms
  Maria Gabriella Gentile
  
  Soy protein effects on renal function in type II diabetic men with nephropathy
  James W. Anderson
  
  Soy isoflavonoids possess biological activities of loop-diuretics
  Octavio J. Alda

Soy and Bone Health
(Chair, John J.B. Anderson)

• A soy protein-containing diet prevents bone loss due to ovarian hormone deficiency
  Bahram H. Arjmandi
  
  Genistein and bone: studies in rat models and bone cell lines
  John J.B. Anderson
  
  Action of genistein and other tyrosine kinase inhibitors in preventing osteoporosis
  Harry C. Blair
  
  Systemic adminstration of genistein partially prevents bone loss in ovariectomized rats via a non estrogen-like mechanism
  Paolo Fanti
  
  Short-term effects of soybean isoflavones on bone in postmenopausal women
  John W. Erdman, Jr.

Soy and Heart Disease : Hypocholesterolemic Effects of Soy
(Chair, Jean-Michel Lecerf)

• Keynote Address : Soy protein and cholesterolemia in man: from Ignatowsky to Brussels
  Cesare Sirtori
  
  Effects of soy protein and isoflavones on plasma lipid profiles in postmenopausal women
  Susan Potter
  
  Role of the main components of whole soybean products, soy protein and soy oil in reducing hypercholesterolemia
  Elzbieta M. Kurowska
  
  Variation in the plasma response to dietary soy protein in normolipidemic men
  Karin Nilausen
  
  Effects of soy proteins on plasma lipoproteins in healthy men
  Sylvie Auboiron
  
  Treatment of hypercholesterolemia in children by diet using soy protein
  Kurt Widhalm

Soy and Heart Disease : Hypocholesterolemic Effects of Soy : Potential Mechanisms
(Chair, Erik Muls)

• Molecular mechanisms for the cholesterol lowering activity of soy
  Cesare Sirtori
  
  Mechanisms for the hypocholesterolemic effect of soy protein in normocholesterolemic and hypercholesterolemic men
  William Wong
  
  Hypocholesterolemic effect of the undigested fraction of soybean protein.
  Shigeru Yamamoto
  
  Effects of soy isoflavones on atherosclerosis: potential mechanisms
  Mary Anthony
  
  The lack of effect of isoflavones on plasma lipid concentration in ovariectomized Cynomolgus monkeys and LDL susceptibility to oxidation
  L. Sulistiyani

September 17

Soy and Heart Disease : Effects Independent of Cholesterol Reduction
(Chair, Bernard Guy-Grand)

• Anti-atherogenic effects of soybean protein: peroxidizability, LDL size and platelet aggregation
  Takemichi Kanazawa
  
  The role of tempe on lipid profile and lipid peroxidation
  Mary Astuti
  
  Antioxidant properties of dietary phenolic agents in a human LDL-oxidation ex vivo model
  Weiqun Wang
  
  Effects of isoflavones on LDL-cholesterol in vitro but not in vivo
  Alan Chait
  
  Genistein inhibits reactive oxygen species (ROS) formation during activation of rat platelets in whole blood.
  Norberta Schoene

Soy and Cancer : Animal Studies
(Chair, Marcel Roberfroid)

• Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein and calcium
  Maurice Bennink
  
  Soy protein isolates and genistein: effects on initiation, promotion and progression of cancer.
  Daniel Gallaher
  
  Effects of dietary soy protein isolates (SPI), genistein and 1,4-phenylenebis(methylene)seleno cyanate (p-XSC) on the levels of 7,12-dimethylbenz(a)anthracene (DMBA)-DNA binding in mammary glands of female CD rats
  Pramod Upadhyaya
  
  Genistein suppresses chemically-induced mammary cancer
  Coral A. Lamartiniere
  
  Paradoxical effects of the soy phytoestrogen genistein on growth of human breast cancer cells in vitro and in vivo.
  William Helferich
  
  Soy isoflavone extract suppresses fumonisin B1-promoted rat hepatocarcinogenesis
  Susan Hendrich
  
  Dietary soy in the prevention of prostate cancer in animal models
  Risto Santti
  
  Soy and Cancer : Soybean Anticarcinogens/Anticancer Mechanisms
  (Chair, Bernard Szuhai)
  
  Keynote Address :
  The Bowman-Birk Inhibitor from soybeans as an anticarcinogenic agent
  Ann R. Kennedy
  
  BBI - the trypsin- and chymotrypsin-inhibitor from soybean: friend or foe?
  Yehudith Birk
  
  Anticarcinogenic properties of plant saponins
  A. Venket Rao
  
  Genistein can induce MCF-7 breast carcinoma cell differentiation or death, depending on dose
  Andreas I. Constantinou
  
  Mechanism of action of the soy isoflavone genistein at the cellular level
  Stephen Barnes

September 18

Soy and Cancer : Soy Consumption and Cancer Risk: Human Studies
(Chair, Jaak Janssens)

• Evaluation of soy protein in risk reduction for colon cancer and cardiovascular disease: preliminary results.
  Maurice Bennink
  
  Stimulatory effects of soy protein isolate on breast fluid secretion
  Nickolas L. Petrakis
  
  The effects of soy supplementation on epithelial proliferation in the normal human breast.
  Danielle F. McMicheal-Phillips
  
  Tofu and risk of breast cancer in Asian-Americans
  Anna Wu
  
  The association of dietary phytoestrogens with the risk for endometrial cancer
  Jean Hankin
  
  A double-blind, clinical trial of the effects of soy protein on risk parameters for prostate cancer
  Stephen Barnes
  
  A pilot study of genistein/soy protein isolate in the treatment of hereditary hemorrhagic telan-giectasia (HHT): possible efficacy in HHT-associated epistaxis, gastrointestinal hemorrhage and migraine.
  Joshua R. Korzenik

Hormonal Effects of Soy : Premenopausal Studies
(Chair, Margo Woods)

• Metabolic and hormonal response to elite female gymnasts during strenuous training and supplementation with SUPRO brand isolated soy protein
  Valentin Stroescu
  
  Endocrine-modifying effects of isoflavones
  Aedin Cassidy
  
  Reductions in steroid and gastrointestinal hormone levels in men and premenopausal women with soya consumption for one month
  Lee-Jane Lu
  
  Effects of dietary soy isoflavones on estrogen action in premenopausal women
  Mindy Kurzer

Hormonal Effects of Soy : Postmenopausal studies
(Chair, Mindy Kurzer)

• Effects of mammalian and plant estrogens on mammary glands and uteri of macques
  Delores Foth
  
  Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat
  Alice Murkies
  
  The potential use of a dietary soy supplement as a post-menopausal hormone replacement therapy
  Gregory L. Burke
  
  Effect of a dietary soy bar on menopausal symptoms
  Margo Woods
  
  A controlled trial of isoflavones for menopausal symptoms
  John Anthony Eden
  

September 19 : Satellite Symposium

Current Understanding of Soy and Infant Health

• Asian use of soy protein formula and soyfoods for infants and children
  Seng Hock Quak
  
  Soy protein for the prevention and treatment of children with cow's milk allergy
  Luisa Businco
  
  Isoflavone content of infant formulas and their metabolic fate
  Kenneth D.R. Setchell
  
  Determination of dietary isoflavone exposure in infants fed breast milk, cow milk or soya formula
  Graham Kelly
  
  Isoflavone and testosterone extraction from disposable diapers: the New Zealand experience
  Clifford Irvine
  
  Isoflavones in human breast milk and other biological fluids after soy consumption
  Adrian Franke
  
  Debate on possible hazards of soy infant formulas: a view from New Zealand
  John Birkbeck
  
  The Developmental Toxicity of Phytoestrogens in Experimental Animals:
  Are there concerns for humans?
  Daniel Sheehan
  
  Phytoestrogens and development in animals: Is there a biological boundry between concern and comfort regarding developmental effects of exogenous hormonal mimics?
  Claude Hughes
  
  A review of soy infant formula feeding
  Samuel Fomon
  
  

Soybean Isoflavones :
Levels in Foods and Pharmacokinetics

• Soy isoflavones in foods: quality assurance in analysis
  Patricia Murphy
  
  Isoflavones quantification by capillary electrophoresis in soybean seeds: effects of variety and environment
  Thierry Aussenac
  
  Chemical modification of isoflavones in soyfoods during cooking and processing
  Lori Coward
  
  Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion in humans
  Joanne Slavin
  
  Pharmacokinetics of genistein and daidzein in rats
  Roger King
  
  Short half-lives and gender differences of excretion of soya isoflavones in humans
  Lee-Jane Lu
  
  Metabolism of isoflavonoids in target cells
  Stephen Barnes

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Indiana Soybean Board