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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
SCIENTIFIC PROGRAM
(Oral Abstracts)Soy and Heart Disease :
Hypocholesterolemic Effects of SoyEffects of Soy Proteins on Plasma Lipoproteins in Healthy Men
S. Auboiron1,3, I. Catala2,3, C. Juste2, E. Bornet3, T. Corring2, B. Guy-Grand1.
1 Nutrition Department, Hôtel-Dieu, 750004 Paris, France.
2 LEPSD, INRA, 78352 Jouy en Josas Cedex, France
3 Nutrition & Health Service, Eridania Béghin-Say, B-1800 Vilvoorde, Belguim.The hypocholesterolemic effects of soy protein have been demonstrated in a variety of animal models, but not so obviously in humans. We compared the effect of animal versus vegetable proteins on plasma lipoproteins in healthy men. For this purpose, 12 healthy young men (29.0 +/- 1.6y, BMI = 22.7 = 0.9 kg/m2) participated in a cross-over design protocol. The subjects fed an isocaloric diet where proteins were either mainly from animal origin or mainly from soya origin for 2 two-week periods, separated by 1 two-week interval on their usual diet. At the end of each dietary period, after an overnight fasting, blood samples were collected to measure plasma lipids and lipoprotein classes (VLDL, IDL, LDL, HDL2, HDL3) after separation by density gradient ultracentrifugation. Body weight and food intake remained constant throughout the study. No difference between animal and soy proteins was observed for plasma lipids. No variation was noted in the plasma concentration of different lipoprotein classes. But soy proteins induced a decreasing TG content of LDL: 3.7 +/- 0.4 vs 6.2 +/- 0.8% of total particle (p<0.05), while the CE content increased: 43.0 +/- 0.9 vs. 38.0 +/-1.2 % of total particle (p<0.05). In contrast, we observed a decreasing FC content of HDL3; 2.6 +/- 0.2 vs 4.4 +/- 0.5% of total particle (p<0.05). Thus, in healthy men fed a cholesterol-poor diet, soy proteins did not act directly on cholesterolemia via LDL as shown in animals and hypercholesterolemic subjects. However, soy proteins seemed to induce modifications in LDL and HDL3 composition.
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