Scientific Program (Oral Abstracts) | Poster Abstracts | Speaker List
SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
SCIENTIFIC PROGRAM
(Oral Abstracts)Soy and Cancer
Animal studiesGenistein Suppresses Chemically-Induced Mammary Cancer
Coral A. Lamartiniere, W. Britton Murrill and Nadine M. Brown.
Department of Pharmacology and Texicology. University of Alabama at Birmingham, Birmingham, AL 35294-0019.Breast cancer is the most common cancer in females and is the second leading cause of cancer death among women. Yet, Asian women, consuming a traditional diet high in soy products have a low incidence of breast cancer. Asians who emigrate to the United States and adopt a western diet lose
this protection. Using the dimethybenz(a)anthracene mammary cancer model, we have investigated the potential of genistein, a component of soy, to protect against the development of mammary cancer. Our results demonstrated that prepubertal genistein treatment resulted in decreased incidence and numbers of tumors/rat. Mammary whole mount analysis showed that genistein treatment resulted in mammary glands of adult rats developing fewer terminal end buds and more lobules II. Terminal end buds are the least differentiated and most susceptible terminal ductal structures in the mammary gland. The lobules are more differentiated and less susceptible to carcinogenesis. Cell proliferation studies with bromodeoxyuridine (BrdU) showed that terminal end buds from mammary glands of 50 day old females treated with genistein had significantly fewer cells in S-phase of the cell cycle. Animals treated prepubertally with genistein as compared to vehicle spent more time in the estrus phase of the estrus cycle, although all animals did cycle. In 50 day old females, circulating estradiol-17 and progesterone concentrations, and ovarian follicular development were not significantly altered by
genistein treatment Prepubertal genistein exposure resulted in a slight but not significant decrease in fertility. We conclude that genistein treatment during the prepubertal period can suppress the development of chemically-induced mammary cancer by causing early gland development and cell differentiation, without toxicity to the endocrine/reproductive system.
Soy Symposium Home http://www.ind.com/soy/symposium
U.S. Soyfoods Directory http://www.ind.com/soy
WebMaster: Roger H. Stevens roger@ind.com
© Copyright 1996 Indiana Soybean Board