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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASE

September 15-18, 1996
Brussells, Belgium

SCIENTIFIC PROGRAM
(Oral Abstracts)

Hormonal effects of Soy
Postmenopausal Studies

Effects of Mammalian and Plant Estrogens on Mammary Glands and Uteri of Macaques
Foth, D; Cline, J.M. Ernst-Moritz-Arndt University, Greifswald, Germany, and Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.

In a recent study of hormonal replacement therapy and its alternatives, adult, surgically postmenopausal female macaques (Macaca fascicularis) were treated continuously with either estradiol (E2), isoflavone-enriched soy isolate (SBE), or E2+SBE. Doses were equivalent on a caloric basis to 1 mg/woman/day for estradiol, and 148 mg/woman/day for soy isoflavones.
After 6 months of replacement therapy histopathologic, morphometric and immunohistochemical measurements of endometrium and mammary glands were done.

Increases in endometrial thickness, gland area, and epithelial proliferation were induced by E2 and E2+SBE. Morphometric changes were accompanied by increased epithelial Ki67 staining in the E2 treated group. The effects of E2 were partially antagonized by SBE (manifested as decreased Ki67 staining). Mammary gland proliferation was induced by E2 and E2 and SBE, morphometric and immunohistochemical measures of proliferation were in agreement in both issues. The effects of E2 were antagonized by SBE in the mammary gland.
Nuclear estrogen receptor (ER) staining of both tissues showed no significant differences between E2, SBE, and SBE + E2 treated macaques. ER labeling was apparent in the SBE group. In the E2 and E2 + SBE treated animals there was an increase in the nuclear staining of progesterone receptor (PGR) of mammary tissue and endometrium. In the endometrium, we saw a decrease in the nuclear PGR staining: superficial glands SBE group: 2,4 +/- 7,59 compared to 21,5 +/- 28,00 % labeled cells control group.

Conclusion: In this primate model SBE treatment did not induce proliferation in endometrium and mammary tissue. The results indicate that SBE may have antiproliferative effects in the endometrim and mammary gland when given along with exogenous estrogen.

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