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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
POSTER ABSTRACTSStimulation by soyabean lecithin of cholesterol transfer from plasma to biliary compartment: mechanisms of cholesterol- and triglyceride lowering effects in the liver.
CHANUSSOT F. 1, POLICHETTI E.1, DOMINGO N.1, JANISSSON A. 1, LECHENE DE LA PORTE P. 1, LAFONT H. 1, LUNA A. 2, LA DROITTE P. 2
1: INSERM U.130, 18 avenue Mozart, 13009 Marseille (France)
2: Nutrition et santé, B.P. 106, route de Castelnaudary, 31250 Revel (France)
The aim of this study was to underscore the mechanisms of stimulation by soyabean lecithin of cholesterol transfer from the plasma toward to the bile, in the model of hypercholesterolemic rabbit.
Male New Zealand white rabbits were fed for 10 weeks diets enriched with 0.2% cholesterol and 5% saturated lard triglycerides (S), 5% polyunsaturated soyabean triglycerides (HS), or 5% polyunsaturated soyabean pure lecithin (LE).
LE diet significantly decreased (-VLDL-cholesterol and -triglycerides, compared to the HS diet. In gallbladder bile, levels of phospholipids, bile salts and cholesterol were significantly increased by LE diet, compared to the HS diet. In addition, hepatic HMG CoA reductase activity was not increased by soyabean lecithin, and there was no additional hepatic accumulation of lipid rich vesicles.
At the intrahepatic level, polyunsaturated lecithin is directly implicated in the recruitment of triglyceride related-fatty acid and cholesterol. This process implies reacylation in a great extent of lyso-PC into PC. PC and unesterified cholesterol are finally discharged into the bile.
This nutritional adaptation is APF dependent. APF is a physiological protein parameter, closely associated with lipids in bile and plasma. In a previous work carried out in rat fed soyabean lecithin diet, APF level decreased in plasma and liver plasma membranes, and increased in the biliary canalicular membranes and bile, in comparison to triglyceride diet. Such metabolic changes are related to the ability of APF to bind and carry unesterified cholesterol and PC in high proportions, from the plasma to the liver and bile.
Thus, soyabean lecithin could be considered as an efffective nutrient in dietetic treatment of mild hyperlipidemia, by a specific action at the hepatic cellular level.
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