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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
POSTER ABSTRACTSThe effects of soy isoflavone intake on bone metabolism in post- menopausal women
J.C. Gallagher, K. Rafferty, M. Wilson, Bone Metabolism Unit, Creighton University, Omaha, NE USA 68131
Previous studies have shown that inclusion of a soy protein isolate with isoflavonoids in the diet prevents ovarlectomy-induced bone loss in rats. We initiated a study is to determine the effect of a varying soy isoflavone intake on bone metabolism in healthy post-menopausal women, jusing a soy protein dietary supplement.
65 healthy post-menopausal women volunteers were recruited, in the study design, subjects will consume 40g of soy protein per day for a nine month intervention period, followed by a six month period during which soy supplementation is discontinued and previous eating patterns are resumed. Subjects were assigned in a double blind randomized fashion to a daily soy protein supplement kof 40 g soy genistein and daidzein. (Protein Technologies,Intl.) The protein is given in powder form and consumed in two equal 20 g doses. In order to accommodate the addition of 40g protein to the diet, the women were asked to follow a soy-free vegetarian diet providing 30g protein per day, for a daily total of 70g protein.
Baseline bone density scans of the spine and the hip will be obtained from each subject, as well as urine and blood samples measuring bone markers, lipids and isoflaves. Each subject completes a baseline 7-day food diary and a 7-day hot flash diary. At three month intervals the blood/urine measurements and diaries are repeated; bone densitometry is repeated at the end of the intervention and follow-up phases. Subjects were randomized form March-June, 1996, and will conclude the intervention phase of the study from November, 1996 - Feb.1997. The use of soy could represent and alternative, non-pharmacological mode of therapy for prevention of osteoporosis.
Supported in part by grants from the Nebraska Soybean Board, and Protein Technologies International
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