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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
POSTER ABSTRACTSTolerance of soy formulas with reduced phytate/phytoestrogens fed to healthy, term infants
Janas L, Ostrom KM. Ross Products Division, 625 Cleveland Ave., Columbus OH 43215, U.S.A.
A randomized, double-masked, 3-week study was conducted in 145 healthy, term infants aged 2-5 weeks to assess short term tolerance and acceptability of soy formulas differing in the manufacturing processes used to reduce phytate in soy protein isolate. One process lowered both phytate and phytoestrogens. Infants were fed a standard milk bases formula (M) for a 1 week baseline period and then for two weeks were fed either a standard soy-bases formula (S), a low phytate soy isolate formula (with phytoestrogens) (LP), or a hydrolyzed soy isolate formula (with phytate and phytoestrogens) (HS). All soy formulas contained soy/coconut oils and com syrup/sucrose as the fat and carbohydrate blends, respectively. Primary outcome variables were stool characteristics, formula intake, and incidence of spit up and vomit; secondary bariables wereweight gain and parental responses to a feeding tolerance questionnaire. Formula intake and incidence of spit up and vomit did not differ among the groups at baseline or during the study period. Mean stool rank consistency (1=watery, 2=loose/mushy, 3=soft, 4=formed, 5=bard) was similar (2.8 - 3.1) among the groups during the baseline feeding of M. Mean stool rank consistency was lower (softer stools) for infants fed HS, 2.1. compared to 2.8 for S and LP, and 2.5 for LPPE. Parents associated HS with watery (HS>LP, P<0,05) and excessively freguent stools. Parents reported that infants fed LP had increases constipation compared to baseline. Infants fed LPPE had less constipation than when fed M during baseline. Mean weight gains for alle formula groups were similar at the end of baseline and the end of the 14-day study period. In conclusion, HS produces softer stools whereas removing phytate and phytoestrogens, orphytate only, resulted in formulas with minimal effects on tolerance and no effects on short-term weight gain. Supported by Ross Products Division, Abbott Laboratories.
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