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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
POSTER ABSTRACTSEFFECTS OF DAIDZEIN ON MUSCLE GROWTH AND SOME ENDOGENOUS HORMONE LEVELS IN RATS
J. Wang and Z. K. Han
Dept. of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095 P.R. China.
76 Wistar rats (male 28, female 12 and male castrated 26), 50 days of age, were used to determine the effects of daidzein on muscle growth and some endogenous hormone levels. Daidzein (3mg/100g body weight) dissolved in 10 % 1,2-propylene glycol was injected subcutaneously for 16 days. To the male rats, body weigth gain and feed to gain ratio of treatment groups improved by 14.7 (P<0.05) and 12.0% (P<0.05) compared of those of control groups (10% 1,2-propylene glycol), hind leg muscle weight, total RNA content of hind leg muscle increased significantly, and no apparent difference was found in total DNA content. Blood urea nitrogen decreased significantly, whereas serum testosterone, estradiol, Beta-endorphin and growth hormone increased obviously. To the castrated male rats, no considerable differences were found in body weight gain and hind leg muscle weight, although concentrations of serum growth hormone, Beta-endorphin and testosterone increased significantly. However, the testosterone level of castrated male rats was about 8.0% of that of intact male rats. To the female rats, the average daily body weight gain decreased by 19.0% (P<0.01), the levels of serum testosterone, estradiol and growth hormone significantly de- creased. The results showed that the effects of daidzein on muscle growth and some endogenous hormone levels in rats exhibited sex difference. The promoting effect of daidzein on muscle growth of male rats seems depending on the function of testis.
KEY WORDS: daidzein, rat, muscle growth, testosterone, growth hormone, estradiol, Beta-endorphin
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