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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
POSTER ABSTRACTSGenistein Inhibition of Prostate Cancer Cell Growth and Metastasis In Vivo.
Rosemary Schleicher, Ming Zheng, Ming Zhang and Coral A. Lamartiniere. Emory University and VAMC, Atlanta, Georgia 30033, and University of Alabama at Birmingham, Birmingham, Alabama 35294. USA.
It has been reported that the soybean component, genistein, inhibits the growth of several rat and human prostate carcinoma cell lines in vitro. Because soy consumption is high in countries in which prostate cancer incidence is low, it is important that more information be gathered about the potential inhibitory effect of this substance in vivo. A transplantable rat carcinoma cell line was used to examine the effect of genistein on prostate cancer growth and metastasis. Lobund -Wistar rats were injected s.c. with 10*10-6 K1 prostate carcinoma cells in the left and in the right flanks of male Lobund-Wistar rats. Genistein at 50 mg/kg B.W. was administered in dimethylsulfoxide (DMSO) under the skin in the dorsal scapular area every 12 hr starting at the time of tumor cell transplantation. Control animals were injected at the same frequency with 0.1 ml DMSO. Genistein had a significantly inhibitory effect on the growth of the prostate carcinoma. Furthermore, fewer animals developed invasive tumors in the genistein-treated group. There were also fewer cased with lymph node metastased and no genistein -treated animals developed lung metastases compared with the control group. Evidence of estrogenic effect was apparent in the rats treated with genistein, including increased pituitary weight, decreased accessory sex gland complex weight, decreased testis weight, and decreaed body weight. Serum testosterone levels were uniformly undetectable in the genistein-treated rats, while 50% of controls had detectable levels. Serum prostate-specific (tartrate-inhibitable) acid phosphatase activity was also lower in the genistein-treated rats, reflecting a combination of smaller prostates, seminal vesicles and prostate tumors. In vitro, genistein directly inhibited the growth of the K1 prostate cancer cells with an IC50 of 7 mg/ml. These data suggest that genistein may be useful treatment to inhibit the growth of prostate cancer and delay its metastasis.
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